If you are a business owner or accountant, you may need to run a 1099 report in QuickBooks Desktop in order to accurately report payments made to independent contractors. This report is required by the IRS and must be filed by the end of January each year. Knowing how to run a 1099 report in QuickBooks Desktop will help you ensure that you are compliant with IRS regulations and that you have all the necessary information to file your taxes.