Set up email interest Activist Codes to segment email audiences and send targeted emails based on a contact's selected interests.
This limits the risk of people unsubscribing from everything if they want to just limit or narrow communications. Instead of emailing your whole database every newsletter, you can set up codes to have contacts select which lists they want to be on by updating their subscription settings. Then, you can send them only emails they've expressed interest in.
For example, here is what email interest options look like on an online actions sign up form.